Nrxn3^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Nrxn3^tm1Sud
• Name: neurexin III; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3042720
• Gene: Nrxn3 Location: Chr12:88689646-90301709 bp, + strand Genetic Position: Chr12, 42.94 cM
• Alliance: Nrxn3^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89452
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Immunoblotting of mutant brain confirmed lack of protein expression. (J:89452)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrxn3 Mutation: 80 strains or lines available

References

• Original: J:89452 Missler M, et al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003 Jun 26;423(6943):939-48
• All: 11 reference(s)