Fkbp8^tm1Tili
Targeted Allele Detail

Summary

• Symbol: Fkbp8^tm1Tili
• Name: FK506 binding protein 8; targeted mutation 1, Tiansen Li
• MGI ID: MGI:3042750
• Synonyms: Fkbp8-
• Gene: Fkbp8 Location: Chr8:70980374-70987978 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Fkbp8^tm1Tili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89364
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were deleted and replaced with a neo cassette via homologous recombination. RT-PCR and immunoblot analysis confirmed the absence of RNA and protein expression in homozygotes. (J:89364)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp8 Mutation: 22 strains or lines available

References

• Original: J:89364 Bulgakov OV, et al., FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development. 2004 May;131(9):2149-59
• All: 3 reference(s)