Nrxn1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Nrxn1^tm1Sud
• Name: neurexin I; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3042794
• Synonyms: Nrxn1alphaKO, SKO2
• Gene: Nrxn1 Location: Chr17:90341059-91400499 bp, - strand Genetic Position: Chr17, 59.73 cM
• Alliance: Nrxn1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45298
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Protein was undetected by Western blot analysis of mutant mice. (J:45298)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrxn1 Mutation: 98 strains or lines available

References

• Original: J:45298 Geppert M, et al., Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J Biol Chem. 1998 Jan 16;273(3):1705-10
• All: 28 reference(s)