Otx2^{tm7(OTX1)Asim}
Targeted Allele Detail

Summary

• Symbol: Otx2^{tm7(OTX1)Asim}
• Name: orthodenticle homeobox 2; targeted mutation 7, Antonio Simeone
• MGI ID: MGI:3042842
• Synonyms: hOtx1^2FL
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^{tm7(OTX1)Asim} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89361
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A human OTX1 cDNA flanked by the Otx2 5' and 3' UTR's replaced all the coding sequence and introns. Only 50 bp of poladenylation signal is duplicated in this allele. This allele expresses the human OTX1 protein under Otx2 transcriptional control. (J:89361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:89361 Acampora D, et al., OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Gene Expr Patterns. 2003 Aug;3(4):497-501
• All: 1 reference(s)