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Ckbtm1Bew
Targeted Allele Detail
Summary
Symbol: Ckbtm1Bew
Name: creatine kinase, brain; targeted mutation 1, Be Wieringa
MGI ID: MGI:3042843
Synonyms: B-CK-
Gene: Ckb  Location: Chr12:111635795-111638772 bp, - strand  Genetic Position: Chr12, 61.09 cM
Alliance: Ckbtm1Bew page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89399
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 including the translation start site was deleted and replaced with a neo-cassette via homologous recombination. Absence of RNA expression and enzyme activity were confirmed by northern blot analysis and activity assays. (J:89399)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ckb Mutation:  26 strains or lines available
References
Original:  J:89399 Jost CR, et al., Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. Eur J Neurosci. 2002 May;15(10):1692-706
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory