Hrtpq1^L6
QTL Variant Detail

Summary

• QTL variant: Hrtpq1^L6
• Name: heart weight percentage QTL 1; L6
• MGI ID: MGI:3042966
• QTL: Hrtpq1 Location: Chr3:10249221-83184946 bp Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased heart weight percentage compared to M16i. (J:87793)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Hrtpq1 may also be consistent with an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 3, QTLs for spleen weight (Splq6), liver weight (Lvrq5), heart weight percentage (Hrtpq1), and kidney weight (Kidq7) were identified. Splq6 maps to 22.1 cM between D3Mit130 and D3Mit97 (LOD=4.8) with L6-derived alleles conferring dominantly inherited decreased spleen weight. The confidence interval of Splq3 spans 10 cM -33.2 cM. Lvrq5 maps to 24.1 cM between D3Mit130 and D3Mit97 (LOD=5.3) with L6-derived alleles conferring recessively inherited decrease in liver weight. The confidence interval of Lvrq5 spans 14 cM - 44.7 cM. Hrtpq1 maps to 30.2 cM between D3Mit130 and D3Mit97 (LOD=3.5) with L6-derived alleles conferring dominantly inherited increase in heart weight percentage. The confidence interval of Hrtpq1 spans 16 cM - 53 cM. Kidq7 maps to 53 cM between D3Mit97 and D3Mit18 (LOD=3.5) with L6-derived alleles conferring recessively inherited decrease in kidney weight. The confidence interval of Kidq7 spans 22.1 - 65.4 cM.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)