Lwq22^L6
QTL Variant Detail

Summary

• QTL variant: Lwq22^L6
• Name: liver weight QTL 22; L6
• MGI ID: MGI:3042969
• QTL: Lwq22 Location: Chr4:17892616-88982216 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased liver weight compared to M16i. (J:87793)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 4, QTLs for liver weight (Lvrq9, Lvrq8) and kidney weight (Kidq4) were identified. Lvrq9 maps to 32.6 cM (LOD=3.9) between D4Mit1 and D4Mit27, and Lvrq8 maps to 49.3 cM (LOD=4.0) between D4Mit27 and D4Mit64. L6-derived alleles confer recessively inherited decrease in liver weight at both Lvrq9 and Lvrq8. The confidence interval of Lvrq9 spans 15.3 cM - 42.5 cM and the confidence interval of Lvrq8 spans 42.5 cM - 58.2 cM. Kidq4 maps to 42.5 cM (LOD=5.3) between D4Mit1 and D4Mit27 with L6-derived alleles conferring dominantly inherited decrease in kidney weight. The confidence interval of Kidq4 spans 19.5 cM - 52.1 cM.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)