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Epfq5L6
QTL Variant Detail
Summary
QTL variant: Epfq5L6
Name: epididymal fat pad weight QTL 5; L6
MGI ID: MGI:3042983
QTL: Epfq5  Location: Chr7:33497727-58148965 bp  Genetic Position: Chr7, Syntenic
Variant
origin
Strain of Specimen:  L6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased epididymal fat pad weight compared to M16i. (J:87793)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 7, QTLs for kidney weight (Kidq5, Kidq6), spleen weight (Splq7), liver weight (Lvrq6) and epididymal fat pad weight (Epfq5) were identified. Kidq5 and Kidq6 mapped to 15 cM (LOD=5.3) between D7Mit55 and D7Mit91 and to 63.5 cM (LOD=3.8) between D7Mit11 and D7Mit105, respectively. L6-derived alleles confer recessively inherited decrease in kidney weight at Kidq5 and recessively inherited increase in kidney weight at Kidq6. Splq7 maps to 16.6 cM (LOD=4.5) between D7Mit55 and D7Mit91 with L6-derived alleles conferring recessively inherited decrease in spleen weight. Lvrq6 mapped to 21.5 cM (LOD=5.0) between D7Mit55 and D7Mit91 with L6-derived alleles conferring dominantly inherited decrease in liver weight. Epfq5 mapped to 21.5 cM (LOD=3.4) between D7Mit55 and D7Mit91 with L6-derived alleles conferring dominantly inherited decrease in epididymal fat pad weight.

References
Original:  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory