Lrp6^Gw
Chemically induced Allele Detail

Summary

• Symbol: Lrp6^Gw
• Name: low density lipoprotein receptor-related protein 6; Gwazi
• MGI ID: MGI:3043026
• Gene: Lrp6 Location: Chr6:134423439-134543876 bp, - strand Genetic Position: Chr6, 65.37 cM
• Alliance: Lrp6^Gw page

Mutation origin

• Strain of Origin: C3H.Cg-Foxq1^sa/H

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a mis-sense (A to G) mutation at nucleotide 1862 (accession #BC060704) that results in the amino acid substitution of glycine for aspartic acid at position 549 (D549G). (J:170646)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp6 Mutation: 95 strains or lines available

Notes

Mutation arose on mice homozygous for the satin locus (closed colony segregating C3H/HeH and 101/H alleles).

References

• Original: J:93195 Bogani D, et al., New semidominant mutations that affect mouse development. Genesis. 2004 Oct;40(2):109
• All: 3 reference(s)