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Splq4M16i
QTL Variant Detail
Summary
QTL variant: Splq4M16i
Name: spleen weight QTL 4; M16i
MGI ID: MGI:3043099
QTL: Splq4  Location: Chr9:63239711-120191934 bp  Genetic Position: Chr9, Syntenic
Variant
origin
Strain of Specimen:  M16i
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 9, spleen weight QTL Splq4 mapped to 49.7 cM (LOD=5.6) between D9Mit105 and D9Mit19 with L6-derived alleles conferring dominantly inherited decrease in spleen weight. The confidence interval of Splq4 spans 35 cM - 58.4 cM.

References
Original:  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory