Hrtq3^L6
QTL Variant Detail

Summary

• QTL variant: Hrtq3^L6
• Name: heart weight QTL 3; L6
• MGI ID: MGI:3043103
• QTL: Hrtq3 Location: Chr10:12704051-84079784 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased heart weight compared to M16i. (J:87793)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 10, QTLs for kidney weight percentage (Kidpq2), heart weight (Hrtq3), subcutaneous fat percentage (Scfpq1), liver weight (Lvrq4), and testis weight (Tesq3) were identified. Kidpq2 mapped to 11.8 cM (LOD=3.4) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited decrease in kidney weight percentage. Hrtq3 mapped to 27.3 cM (LOD=4.2) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited decrease in heart weight. The confidence interval of Hrtq3 spans 13.7 cM - 44.6 cM. Scfpq1 maps to 33.1 cM (LOD=3.9) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited increase in subcutaneousfat percentage. The confidence interval of Scfpq1 spans 20.5 cM - 55.3 cM. Lvrq4 mapped to 37 cM (LOD=5.5) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited decrease in liver weight. The confidence interval of Lvrq4 spans 26.3 cM - 53.2 cM. Tesq3 mapped to 69 cM (LOD=3.9) between D10Mit65 and D10Mit35a with L6-derived alleles conferring dominantly inherited increase in testis weight.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)