Lwq20^L6
QTL Variant Detail

Summary

• QTL variant: Lwq20^L6
• Name: liver weight QTL 20; L6
• MGI ID: MGI:3043119
• QTL: Lwq20 Location: Chr11:12268637-118022724 bp Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased liver weight compared to M16i. (J:87793)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Lvrq7 may also be consistent with an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 11, QTLs for epididymal fat pad weight (Epfq4), kidney weight percentage (Kidpq1), liver weight (Lvrq7), and subcutaneous fat pad weight (Scfq3) were identified in the interval between D11Mit2 and D11Mit4. Epfq4 mapped to 17.4 cM (LOD=3.5) with L6-derived alleles conferring recessively inherited decrease in epididymal fat pad weight. Kidpq1 mapped to 19.9 cM (LOD=4.5 with L6-derived alleles conferring dominantly inherited increase in kidney weight percentage. The confidence interval of Kidpq1 spans 6.2 cM - 39.1 cM. Lvrq7 mapped to 24.9 cM (LOD=4.6) with L6-derived alleles conferring recessively inherited decrease in liver weight. The confidence interval of Lvrq7 spans 11.1 cM - 45.4 cM. Scfq3 mapped to 24.9 cM (LOD=4.1) with L6-derived alleles conferring recessively inherited decrease in subcutaneous fat pad weight. The confidence interval of Scfq3 spans 9.9 cM - 47.5 cM.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)