Lwq23^M16i
QTL Variant Detail

Summary

• QTL variant: Lwq23^M16i
• Name: liver weight QTL 10; M16i
• MGI ID: MGI:3043129
• QTL: Lwq23 Location: Chr12:80956708-113383533 bp Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Lvrq10 may also be consistent with an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 12, liver weight QTL Lvrq10 mapped to 53.2 cM (LOD=3.5) between D12Mit5 and D12Mit8 with L6-derived alleles conferring dominantly inherited decrease in liver weight.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)