Tesq1^L6
QTL Variant Detail

Summary

• QTL variant: Tesq1^L6
• Name: testis weight QTL 1; L6
• MGI ID: MGI:3043132
• QTL: Tesq1 Location: Chr13:20615512-55720517 bp Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased testis weight compared to M16i. (J:87793)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 13, testis weight QTL Tesq1 mapped to 10 cM (LOD=7.2) between D13Mit3 and D13Mit21 with L6-derived alleles conferring recessively inherited decrease in testis weight.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)