Splq9^L6
QTL Variant Detail

Summary

• QTL variant: Splq9^L6
• Name: spleen weight QTL 9; L6
• MGI ID: MGI:3043147
• QTL: Splq9 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased spleen weight compared to M16i. (J:87793)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Splq9 may also be consistent with an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 17, QTLs for spleen weight (Splq9), subcutaneous fat pad weight (Scfq4), and epididymal fat pad weight (Epfq3) were identified in an interval between D17Mit124 and D17Mit10. Splq9 mapped to 21.9 cM (LOD=3.4) with L6-derived alleles conferring recessively inherited decrease in spleen weight. Scfq4 mapped to 21.9 cM (LOD=4.1) with L6-derived alleles conferring dominantly inherited decrease in subcutaneous fat pad weight. Epfq3 mapped to 21.9 cM (LOD=3.8) with L6-derived alleles conferring recessively inherited decrease in epididymal fat pad weight.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)