Hey1^tm1Gess
Targeted Allele Detail

Summary

• Symbol: Hey1^tm1Gess
• Name: hairy/enhancer-of-split related with YRPW motif 1; targeted mutation 1, Manfred Gessler
• MGI ID: MGI:3043217
• Synonyms: Hey1^-
• Gene: Hey1 Location: Chr3:8728419-8732098 bp, - strand Genetic Position: Chr3, 2.15 cM
• Alliance: Hey1^tm1Gess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89444
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame lacZ gene replaced all of exons 2-4 and parts of exons 1 and 5 via homologous recombination. Expression of beta-galactosidase activity is similar to endogenous Hey1 expression. (J:89444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey1 Mutation: 17 strains or lines available

References

• Original: J:89444 Fischer A, et al., The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11
• All: 6 reference(s)