Notch1^tm2Agt
Targeted Allele Detail

Summary

• Symbol: Notch1^tm2Agt
• Name: notch 1; targeted mutation 2, Michael Aguet
• MGI ID: MGI:3043290
• Synonyms: Notch1-
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm2Agt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55400
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 3.5 kb segment including the putative promoter and the exon encoding the signaling peptide were deleted via homologous recombination and Cre-recombinase mediated excison. (J:55400)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:55400 Radtke F, et al., Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999 May;10(5):547-58
• All: 6 reference(s)