Mapt^{tm1(Mecp2)Jae}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm1(Mecp2)Jae}
• Name: microtubule-associated protein tau; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:3043293
• Synonyms: Tau-Mecp2 ki
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm1(Mecp2)Jae} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89593
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mapt^{tm1(Mecp2)Jae} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mecp2 (MGI:99918)

• Mutation details: The mouse Mecp2 coding sequence, a modified Kozak sequence and a neo-cassette were placed in-frame into exon 1 of Mapt via homologous combination. The resulting fusion protein contained the first 31 amino acids of Mapt fused to Mecp2 and was highly expressed in the brain (in post-mitotic neurons), lung, and kidney. (J:89593)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:89593 Luikenhuis S, et al., Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6033-8
• All: 2 reference(s)