Adm^tm1Hku
Targeted Allele Detail

Summary

• Symbol: Adm^tm1Hku
• Name: adrenomedullin; targeted mutation 1, Hiroki Kurihara
• MGI ID: MGI:3043324
• Synonyms: AM^-
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1Hku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89608
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing all of exons 1 through 3 and a portion of exon 4 was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:89608)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:89608 Shindo T, et al., Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation. 2001 Oct 16;104(16):1964-71
• All: 10 reference(s)