Gnas^tm2.1Lsw
Targeted Allele Detail

Summary

• Symbol: Gnas^tm2.1Lsw
• Name: GNAS complex locus; targeted mutation 2.1, Lee S Weinstein
• MGI ID: MGI:3043369
• Synonyms: 1A^-, delta^-6267/-1601
• Gene: Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
• Alliance: Gnas^tm2.1Lsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89923
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed fragment from -6267 to -1601 bp upstream of the translation start site was excised via Cre mediated recombination in vivo, resulting in the deletion of Gnas exon 1A regulatory region which regulates tissue-specific imprinting of Gs-alpha. (J:89923)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnas Mutation: 54 strains or lines available

References

• Original: J:89923 Sakamoto A, et al., Tissue-specific imprinting of the G protein Gsalpha is associated with tissue-specific differences in histone methylation. Hum Mol Genet. 2004 Apr 15;13(8):819-28
• All: 3 reference(s)