Cdk11b^tm1Vjk
Targeted Allele Detail

Summary

• Symbol: Cdk11b^tm1Vjk
• Name: cyclin dependent kinase 11B; targeted mutation 1, Vincent J Kidd
• MGI ID: MGI:3043373
• Synonyms: cdc2l^-, CDK11^p110/p58-
• Gene: Cdk11b Location: Chr4:155709311-155734395 bp, + strand Genetic Position: Chr4, 86.73 cM
• Alliance: Cdk11b^tm1Vjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89908
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 10.3 kb genomic segment including exons 3 - 5 of the locus were replaced with a TK-neo cassette via homologous recombination. Immunofluorescence microscopy analysis confirmed the absence of both the p58 and p110 isoforms. (J:89908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk11b Mutation: 48 strains or lines available

References

• Original: J:89908 Li T, et al., Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Mol Cell Biol. 2004 Apr;24(8):3188-97
• All: 3 reference(s)