Mmel1^tm1Ldg
Targeted Allele Detail

Summary

• Symbol: Mmel1^tm1Ldg
• Name: membrane metallo-endopeptidase-like 1; targeted mutation 1, Luc DesGroseillers
• MGI ID: MGI:3043380
• Synonyms: Nl1-
• Gene: Mmel1 Location: Chr4:154954042-154979985 bp, + strand Genetic Position: Chr4, 85.54 cM, cytoband E2
• Alliance: Mmel1^tm1Ldg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89881
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 823 bp segment including exon 10 and part of exon 11 was deleted and replaced with a PGKneo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygotes. (J:89881)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmel1 Mutation: 36 strains or lines available

References

• Original: J:89881 Carpentier M, et al., Reduced fertility in male mice deficient in the zinc metallopeptidase NL1. Mol Cell Biol. 2004 May;24(10):4428-37
• All: 2 reference(s)