Scn1b^tm1Isom
Targeted Allele Detail

Summary

• Symbol: Scn1b^tm1Isom
• Name: sodium channel, voltage-gated, type I, beta; targeted mutation 1, Lori L Isom
• MGI ID: MGI:3043422
• Synonyms: Beta1 (-)
• Gene: Scn1b Location: Chr7:30815949-30826428 bp, - strand Genetic Position: Chr7, 19.3 cM
• Alliance: Scn1b^tm1Isom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90136
• Parent Cell Line: Pat5 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 as well as the 73 bp of intron 3 that are required for the expression of the Beta1A embryonic splice variant were replaced by a neomycin cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of brain RNA. (J:90136)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1b Mutation: 8 strains or lines available

References

• Original: J:90136 Chen C, et al., Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 2004 Apr 21;24(16):4030-42
• All: 22 reference(s)