Tg(Camk2a-MME)3Selk
Transgene Detail

Summary

• Symbol: Tg(Camk2a-MME)3Selk
• Name: transgene insertion 3, Dennis J Selkoe
• MGI ID: MGI:3043425
• Synonyms: 8xNEP
• Transgene: Tg(Camk2a-MME)3Selk Location: unknown
• Alliance: Tg(Camk2a-MME)3Selk page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-MME)3Selk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MME (4311)

  Mme	(MGI:97004)

• Mutation details: Transgenic mice express human membrane metallo-endopeptidase (MME) under the direction of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter. Transgene expression is approximately 8 fold relative to wildtype controls, as detected by quantitative Western blot analysis and protease activity assay. The levels of soluble alpha beta-amyloid X-40 and soluble alpha beta-amyloid X-42 are reduced in 2 to 3 month old transgenic mice. (J:87150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

Transgenic mice have poor reproductive performance.

In conjunction with Tg(PDGFB-APPSwInd)20Lms, transgenic mice do not develop amyloid beta plaques.

References

• Original: J:87150 Leissring MA, et al., Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18;40(6):1087-93
• All: 2 reference(s)