Trp53^tm1Elee
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Elee
• Name: transformation related protein 53; targeted mutation 1, Eva YHP Lee
• MGI ID: MGI:3043426
• Synonyms: p53^f5&6, p53^flox, p53^fp, p53ko^flox
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Elee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90247
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5 and 6 were flanked by single loxP sites in introns 4 and 6. Recombination of these loxP sites will result in the deletion of codons 123 through 221, which encode part of the DNA-binding domain. (J:90247)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Elee

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:90247 Lin SC, et al., Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004 May 15;64(10):3525-32
• All: 23 reference(s)