Tg(Camk2a-IDE)1Selk
Transgene Detail

Summary

• Symbol: Tg(Camk2a-IDE)1Selk
• Name: transgene insertion 1, Dennis J Selkoe
• MGI ID: MGI:3043428
• Synonyms: 2xIDE
• Transgene: Tg(Camk2a-IDE)1Selk Location: unknown
• Alliance: Tg(Camk2a-IDE)1Selk page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-IDE)1Selk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IDE (3416)

  Ide	(MGI:96412)

• Mutation details: Transgenic mice express human insulin-degrading enzyme (IDE) under the direction of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter. Transgene expression is approximately 2 fold relative to wildtype controls as detected by quantitative Western blot analysis and protease activity assay. The levels of soluble alpha beta-amyloid X-40 and soluble alpha beta-amyloid X-42 are reduced in 2 to 3 month old transgenic mice. (J:87150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The levels of soluble alpha beta-amyloid X-40 and soluble alpha beta-amyloid X-42 are reduced in 2 to 3 month old transgenic mice.

In conjunction with Tg(PDGFB-APPSwInd)20Lms, transgenic mice develop only about half the amyloid beta plaque burden displayed by transgenic mice carrying Tg(PDGFB-APPSwInd)20Lms alone.

References

• Original: J:87150 Leissring MA, et al., Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18;40(6):1087-93
• All: 1 reference(s)