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Tg(Wap-rtTA-cre)10Whl
Transgene Detail
Summary
Symbol: Tg(Wap-rtTA-cre)10Whl
Name: transgene insertion 10, Wen-Hwa Lee
MGI ID: MGI:3043456
Synonyms: TgWAPrtTACre, Wap-cre, WAPCrec, Wap-rtTA-Cre
Transgene: Tg(Wap-rtTA-cre)10Whl  Location: unknown  
Alliance: Tg(Wap-rtTA-cre)10Whl page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase, Transactivator)
Mutation:    Insertion
 
Tg(Wap-rtTA-cre)10Whl expression driven by 1 gene
 
Mutation detailsSequence encoding reverse tetracycline-controlled transactivator (rtTA) was placed under control of the whey acidic protein promoter and in cis configuration with sequence encoding cre recombinase adjoined to an rtTA-inducible CMV promoter. Initial reporter analysis showed cre activity to be completely doxycycline dependent and restricted to the mammary epithelial cells. In contrast, subsequent activity analysis in J:90247 showed doxycycline independent cre activity in a variety of tissues including the mammary gland, brain, liver, and spleen; putatively due to a modification of the transgene and/or the unstable nature of transgene copy number. (J:69330)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wap (species not specified)
Summary of all recombinase alleles driven by Wap.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Tg(Wap-rtTA-cre)10Whl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:69330 Utomo AR, et al., Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat Biotechnol. 1999 Nov;17(11):1091-6
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory