Tg(Wap-rtTA-cre)10Whl
Transgene Detail
|
Symbol: |
Tg(Wap-rtTA-cre)10Whl |
Name: |
transgene insertion 10, Wen-Hwa Lee |
MGI ID: |
MGI:3043456 |
Synonyms: |
TgWAPrtTACre, Wap-cre, WAPCrec, Wap-rtTA-Cre |
Transgene: |
Tg(Wap-rtTA-cre)10Whl Location: unknown
|
Alliance: |
Tg(Wap-rtTA-cre)10Whl page
|
|
|
Transgene Type: |
|
Transgenic (Recombinase, Transactivator) |
Mutation: |
|
Insertion
|
|
|
Tg(Wap-rtTA-cre)10Whl expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
Not Specified |
Wap |
|
|
|
|
Mutation details: Sequence encoding reverse tetracycline-controlled transactivator (rtTA) was placed under control of the whey acidic protein promoter and in cis configuration with sequence encoding cre recombinase adjoined to an rtTA-inducible CMV promoter. Initial reporter analysis showed cre activity to be completely doxycycline dependent and restricted to the mammary epithelial cells. In contrast, subsequent activity analysis in J:90247 showed doxycycline independent cre activity in a variety of tissues including the mammary gland, brain, liver, and spleen; putatively due to a modification of the transgene and/or the unstable nature of transgene copy number.
(J:69330)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Wap
(species not specified)
|
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:69330 Utomo AR, et al., Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat Biotechnol. 1999 Nov;17(11):1091-6 |
All: |
12 reference(s) |
|