Tg(Wap-rtTA-cre)10Whl
Transgene Detail

Summary

• Symbol: Tg(Wap-rtTA-cre)10Whl
• Name: transgene insertion 10, Wen-Hwa Lee
• MGI ID: MGI:3043456
• Synonyms: TgWAPrtTACre, Wap-cre, WAPCre^c, Wap-rtTA-Cre
• Transgene: Tg(Wap-rtTA-cre)10Whl Location: unknown
• Alliance: Tg(Wap-rtTA-cre)10Whl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase, Transactivator)
• Mutation: Insertion
• Tg(Wap-rtTA-cre)10Whl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Wap

• Mutation details: Sequence encoding reverse tetracycline-controlled transactivator (rtTA) was placed under control of the whey acidic protein promoter and in cis configuration with sequence encoding cre recombinase adjoined to an rtTA-inducible CMV promoter. Initial reporter analysis showed cre activity to be completely doxycycline dependent and restricted to the mammary epithelial cells. In contrast, subsequent activity analysis in J:90247 showed doxycycline independent cre activity in a variety of tissues including the mammary gland, brain, liver, and spleen; putatively due to a modification of the transgene and/or the unstable nature of transgene copy number. (J:69330)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Wap (species not specified) Summary of all recombinase alleles driven by Wap. Comparative matrix view of recombinase activities

Tumor Data

List all tumor models in MMHCdb carrying Tg(Wap-rtTA-cre)10Whl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:69330 Utomo AR, et al., Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat Biotechnol. 1999 Nov;17(11):1091-6
• All: 12 reference(s)