Hrtq1^L6
QTL Variant Detail

Summary

• QTL variant: Hrtq1^L6
• Name: heart weight QTL 1; L6
• MGI ID: MGI:3043472
• QTL: Hrtq1 Location: Chr2:20897778-118894840 bp Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: L6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased heart weight compared to M16i. (J:87793)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 2, QTLs for heart weight (Hrtq1, Hrtq2), kidney weight (Kidq1, Kidq3), spleen weight (Splq1, Splq2), subcutaneous fat pad weight (Scfq1), epididymus fat pad weight (Epfq1, Epfq2), liver weight (Lvrq1, Lvrq2), and epididymus fat percentage (Epfpq1) were identified. Hrtq1 maps to 52.2 cM between D2Mit6 and D2Mit133 (LOD=6.4) with L6-derived alleles conferring dominantly inherited decrease in heart weight. The confidence interval of Hrtq1 spans 38 cM - 70.3 cM. Hrtq2 maps to 80.4 cM between D2Mit224 and D2Mit22 (LOD=5.7) with L6-derived alleles conferring recessively inherited decrease in heart weight. The confidence interval of Hrtq2 spans 75.9 cM - 84 cM.

Kidq1 and Kidq3 map to 52.2 cM (LOD=10.3) between D2Mit6 and D2Mit133, and 77.8 cM (LOD=6.8) between D2Mit224 and D2Mit22, respectively. L6-derived alleles confer recessively inherited decrease in kidney weight at both Kidq1 and Kidq3. The confidence interval of Kidq1 spans 42.7 cM - 66.8 cM and the confidence interval of Kidq3 spans 74 cM -81.6 cM.

Splq1 and Splq2 map to 57.9 cM (LOD=6.8) between D2Mit6 and D2Mit133, and 79.1 cM (LOD=5.9) between D2Mit224, and D2Mit22, respectively. L6-derived alleles confer dominantly inherited decrease in spleen weight at both Splq1 and Splq2. The confidence interval of Splq1 spans 45.6 cM - 72.7 cM; the confidence interval of Splq2 spans 74 cM - 83 cM.

Lvrq1 maps to 59.7 cM (LOD=18.9) and Lvrq2 maps to 79.1 cM (LOD=15.1), respectively. Lvrq1 is flanked by D2Mit6 and D2Mit133 and Lvrq2 is flanked by D2Mit224 and D2Mit22. L6-derived alleles confer recessively inherited decrease in liver weight at Lvrq1 and dominantly inherited decrease in liver weight at Lvrq2. The confidenceinterval of Lvrq1 spans 51.2 cM - 69.2 cM and the confidence interval of Lvrq2 spans 76.5 cM - 81.7 cM.

Scfq1 maps to 84 cM between D2Mit22 and D2Mit49 (LOD=7.6) with L6-derived alleles conferring dominantly inherited decrease in subcutaneous fat pad weight. The confidence interval of Scfq1 spans 81.7 cM - 88.9 cM.

Epfq1 and Epfq2 map to 84 cM (LOD=9.5) between D2Mit22 and D2Mit49 and to 97.6 cM (LOD=4.6) between D2Mit49 and D2Mit148, respectively. The confidence interval of Epfq1 spans 79.8 cM - 87.6 cM and the confidence interval of Epfq2 spans 95.5 cM - 102.4 cM.L6-derived alleles confer decreased epididymal fat pad weight with dominant inheritance at Epfq1 and recessive/additive inheritance at Epfq2.

Epfpq2 mapped to 66.8 cM between D2Mit133 and D2Mit224 (LOD=3.8) with L6-derived alleles conferring recessively inherited increase in epididymal fat percentage. The confidence interval of Epfpq2 spans 52.2 cM - 72.7 cM.

References

• Original: J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• All: 1 reference(s)