Ptpn22^tm2Achn
Targeted Allele Detail

Summary

• Symbol: Ptpn22^tm2Achn
• Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 2, Andrew C Chan
• MGI ID: MGI:3043477
• Synonyms: pep-, pep(E1)-
• Gene: Ptpn22 Location: Chr3:103767111-103819563 bp, + strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Ptpn22^tm2Achn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90029
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The translation initiation methionine in exon 1 was mutated from ATGG to CTGC and a puromycin resistance cassette added via homologous recombination. Immunoblot analysis confirmed the absence of wild type or truncated protein in thymocytes and splenocytes from homozygotes. (J:90029)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn22 Mutation: 53 strains or lines available

References

• Original: J:90029 Hasegawa K, et al., PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science. 2004 Jan 30;303(5658):685-9
• All: 13 reference(s)