Ifrd1^tm1Lah
Targeted Allele Detail

Summary

• Symbol: Ifrd1^tm1Lah
• Name: interferon-related developmental regulator 1; targeted mutation 1, Lukas A Huber
• MGI ID: MGI:3043556
• Synonyms: Tis7-
• Gene: Ifrd1 Location: Chr12:40253128-40273184 bp, - strand Genetic Position: Chr12, 18.06 cM
• Alliance: Ifrd1^tm1Lah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89917
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and exon 3 were replaced with an in-frame lacZ and a loxP flanked neo cassette via homologous recombination. Northern and western blot analysis confirmed the absence of mRNA and protein expression. (J:89917)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifrd1 Mutation: 29 strains or lines available

References

• Original: J:89917 Vadivelu SK, et al., Muscle regeneration and myogenic differentiation defects in mice lacking TIS7. Mol Cell Biol. 2004 Apr;24(8):3514-25
• All: 6 reference(s)