Ercc5tm2Shm
Targeted Allele Detail
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Symbol: |
Ercc5tm2Shm |
Name: |
excision repair cross-complementing rodent repair deficiency, complementation group 5; targeted mutation 2, Tadahiro Shiomi |
MGI ID: |
MGI:3043588 |
Synonyms: |
Xpg-delta-ex15 |
Gene: |
Ercc5 Location: Chr1:44186904-44220420 bp, + strand Genetic Position: Chr1, 23.55 cM, cytoband B
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Alliance: |
Ercc5tm2Shm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:89911
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 15 was replaced with an MC1-neo cassette via homologous recombination. This C-terminal truncation removed the last 183 amino acids. Northern analysis detected 2 large mRNA's with 6 or 36 amino acids incorporated after exon 14 but lacking exon 15.
(J:89911)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ercc5 Mutation: |
55 strains or lines available
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Original: |
J:89911 Shiomi N, et al., Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Mol Cell Biol. 2004 May;24(9):3712-9 |
All: |
2 reference(s) |
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