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Apoa2b
Allele Detail
Summary
Symbol: Apoa2b
Name: apolipoprotein A-II; b variant
MGI ID: MGI:3043622
Gene: Apoa2  Location: Chr1:171052623-171053948 bp, + strand  Genetic Position: Chr1, 79.22 cM
Alliance: Apoa2b page
Mutation
origin
Strain of Origin:  various
Mutation
description
Allele Type:    Not Applicable
Mutation:    Not Applicable
 
Mutation detailsThis allele encodes a proline at position 5, a glutamic acid at position 20, a valine at positions 26, 38 and 61. This allele is found on BALB/C, CBA/N, C3H/He, DDD, NZB/N, ICR:slc, SAMP6, and SAMR1 backgrounds, also found in 129, FVB, KK, LP, MRL, NON, NZW, RF. (J:11543, J:92800)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoa2 Mutation:  20 strains or lines available
Notes
This allele shows association with increased plasma cholesterol levels. Plasma HDL concentrations are significantly higher in strains carrying this allele than in other strains J:92800.
References
Original:  J:11543 Higuchi K, et al., Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis. Biochem J. 1991 Oct 15;279(Pt 2):427-33
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory