Epha5^tm1Jgf
Targeted Allele Detail

Summary

• Symbol: Epha5^tm1Jgf
• Name: Eph receptor A5; targeted mutation 1, John G Flanagan
• MGI ID: MGI:3043641
• Synonyms: Epha5^lacZ
• Gene: Epha5 Location: Chr5:84202620-84565241 bp, - strand Genetic Position: Chr5, 43.0 cM
• Alliance: Epha5^tm1Jgf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous gene was disrupted by the insertion of a cassette containing lacZ and PGK-neo. Beta galactosidase activity was detected in mutant mice indicating the production of a fusion protein predicted to consist of the extracellular, transmembrane, and juxtamembrane domains followed by beta-galactosidase. The protein putatively lacks the entire tyrosine kinase and C-terminal domains, but the kinase-independent functions are expetcted to remain intact. (J:90078)

Expression

In Mice Carrying this Mutation:

679 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epha5 Mutation: 71 strains or lines available

References

• Original: J:90078 Feldheim DA, et al., Loss-of-function analysis of EphA receptors in retinotectal mapping. J Neurosci. 2004 Mar 10;24(10):2542-50
• All: 5 reference(s)