S100a4^tm1Amba
Targeted Allele Detail

Summary

• Symbol: S100a4^tm1Amba
• Name: S100 calcium binding protein A4; targeted mutation 1, Noona Ambartsumian
• MGI ID: MGI:3043753
• Synonyms: S100A4^-
• Gene: S100a4 Location: Chr3:90511077-90513349 bp, + strand Genetic Position: Chr3, 39.27 cM, cytoband F1-F2
• Alliance: S100a4^tm1Amba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89563
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single loxP site remained in place of a genomic fragment encompassing the entire coding region (exons 2 and 3) after floxed selection cassette was inserted and subsequntly removed via homologous and cre-mediated recombination. Neither transcript nor protein was detected in various organs or MEFs, respectively. (J:89563)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying S100a4^tm1Amba

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a4 Mutation: 26 strains or lines available

References

• Original: J:89563 EL Naaman C, et al., Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene. Oncogene. 2004 Apr 29;23(20):3670-80
• All: 15 reference(s)