Fbl^{Gt(pGT1-3)1Jca}
Gene trapped Allele Detail

Summary

• Symbol: Fbl^{Gt(pGT1-3)1Jca}
• Name: fibrillarin; gene trap 1, Javier F Caceres
• MGI ID: MGI:3043754
• Synonyms: Fibrillarin-
• Gene: Fbl Location: Chr7:27869135-27878694 bp, + strand Genetic Position: Chr7, 16.67 cM, cytoband A1
• Alliance: Fbl^{Gt(pGT1-3)1Jca} page

Mutation origin

• Mutant Cell Line: ES403
• Germline Transmission: Earliest citation of germline transmission: J:89938
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector Type: gene trap
• Mutation details: The endogenous locus was disrupted by insertion into intron 4 of the pGT1,-2, or-3 retroviral gene trap vector containing a splice acceptor site, beta-geo, and an SV40 poly-A signal. A fusion protein consisting of the N-terminal 132 amino acids of the Fbl protein fused to lacZ is expressed from the mutated locus. (J:71817, J:89938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbl Mutation: 23 strains or lines available

References

• Original: J:89938 Newton K, et al., Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Mol Cell Biol. 2003 Dec;23(23):8519-27
• All: 2 reference(s)