Nr4a3^tm1Wnt
Targeted Allele Detail

Summary

• Symbol: Nr4a3^tm1Wnt
• Name: nuclear receptor subfamily 4, group A, member 3; targeted mutation 1, Astar Winoto
• MGI ID: MGI:3043761
• Synonyms: Nor-1 -
• Gene: Nr4a3 Location: Chr4:48045153-48086447 bp, + strand Genetic Position: Chr4, 26.07 cM, cytoband B2
• Alliance: Nr4a3^tm1Wnt page

Abnormal mesoderm accumulation in E7 Nr4a3^tm1Wnt/Nr4a3^tm1Wnt embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89944
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 3 containing the transcriptional activation domain and part of the DNA binding domain was replaced with a neo cassette via homologous recombination. In situ hybridization confirmed the absence of RNA expression in homozygous embryos. (J:89944)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr4a3 Mutation: 54 strains or lines available

References

• Original: J:89944 DeYoung RA, et al., The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem. 2003 Nov 21;278(47):47104-9
• All: 2 reference(s)