Tfr2^tm1Nsub
Targeted Allele Detail

Summary

• Symbol: Tfr2^tm1Nsub
• Name: transferrin receptor 2; targeted mutation 1, V Nathan Subramaniam
• MGI ID: MGI:3043771
• Synonyms: F
• Gene: Tfr2 Location: Chr5:137568102-137585743 bp, + strand Genetic Position: Chr5, 76.57 cM
• Alliance: Tfr2^tm1Nsub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89758
• Parent Cell Line: C1368 (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites flanked a genomic region encompassing exons 2 through 6. The floxed region encodes the extracellular domain, the transmembrane domain, and most of the intracellular domain. The floxed region also contains a single frt site, a remnant from the excision of an frt-flanked neo cassette used for selection. (J:89758)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfr2 Mutation: 32 strains or lines available

References

• Original: J:89758 Wallace DF, et al., Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system. Genesis. 2004 May;39(1):38-41
• All: 2 reference(s)