Tfr2^tm1.1Nsub
Targeted Allele Detail

Summary

• Symbol: Tfr2^tm1.1Nsub
• Name: transferrin receptor 2; targeted mutation 1.1, V Nathan Subramaniam
• MGI ID: MGI:3043773
• Synonyms: delta
• Gene: Tfr2 Location: Chr5:137568102-137585743 bp, + strand Genetic Position: Chr5, 76.57 cM
• Alliance: Tfr2^tm1.1Nsub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89758
• Parent Cell Line: C1368 (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region encompassing exons 2 through 6, encoding the extracellular domain, the transmembrane domain, and most of the intracellular domain, was deleted via cre-mediated recombination of single loxP sites following exon 1b and exon 6. Protein was undetected by Western blot analysis of liver homogenates obtained from homozygous mutant mice. (J:89758)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfr2 Mutation: 32 strains or lines available

References

• Original: J:89758 Wallace DF, et al., Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system. Genesis. 2004 May;39(1):38-41
• All: 11 reference(s)