Anp32a^tm1Hzo
Targeted Allele Detail

Summary

• Symbol: Anp32a^tm1Hzo
• Name: acidic nuclear phosphoprotein 32 family member A; targeted mutation 1, Huda Y Zoghbi
• MGI ID: MGI:3043774
• Synonyms: Lanp-
• Gene: Anp32a Location: Chr9:62248637-62286084 bp, + strand Genetic Position: Chr9, 33.68 cM
• Alliance: Anp32a^tm1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of eoxn 2. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 2, exon 3, and the neo cassette. Aberrant splicing between exons 1 and 4 is predicted to produce a premature stop codon in exon 4 due to a frameshift. The absence of protein expression was confirmed by western blot analysis of cerebellar extracts. (J:89899)

Tumor Data

List all tumor models in MMHCdb carrying Anp32a^tm1Hzo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anp32a Mutation: 57 strains or lines available

References

• Original: J:89899 Opal P, et al., Generation and characterization of LANP/pp32 null mice. Mol Cell Biol. 2004 Apr;24(8):3140-9
• All: 6 reference(s)