Glra3^tm1.1Umu
Targeted Allele Detail

Summary

• Symbol: Glra3^tm1.1Umu
• Name: glycine receptor, alpha 3 subunit; targeted mutation 1.1, Ulrike Muller
• MGI ID: MGI:3043776
• Synonyms: GlyR alpha3-
• Gene: Glra3 Location: Chr8:56393495-56583105 bp, + strand Genetic Position: Chr8, 29.69 cM
• Alliance: Glra3^tm1.1Umu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89981
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed fragment containing exon 7 and a neo cassette were excised via cre mediated recombination. Immunostaining confirmed the absence of protein in the dorsal horn of the brain in homozygotes. (J:89981)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glra3 Mutation: 39 strains or lines available

References

• Original: J:89981 Harvey RJ, et al., GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science. 2004 May 7;304(5672):884-7
• All: 16 reference(s)