Npc1l1^tm1Swa
Targeted Allele Detail

Summary

• Symbol: Npc1l1^tm1Swa
• Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Scott W Altmann
• MGI ID: MGI:3043784
• Synonyms: NPC1L1(-)
• Gene: Npc1l1 Location: Chr11:6161013-6180143 bp, - strand Genetic Position: Chr11, 3.93 cM
• Alliance: Npc1l1^tm1Swa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin selection cassette replaced a genomic fragment containing bases 790 to 998 of the coding sequence of the gene. RT-PCR analysis on mucosal scrapings of homozygous mice confirmed that no detectable transcript was expressed from this allele. (J:89712)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npc1l1 Mutation: 48 strains or lines available

References

• Original: J:89712 Altmann SW, et al., Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4
• All: 3 reference(s)