Nell2^tm1Mho
Targeted Allele Detail

Summary

• Symbol: Nell2^tm1Mho
• Name: NEL-like 2; targeted mutation 1, Masato Horie
• MGI ID: MGI:3043786
• Synonyms: NELL2-
• Gene: Nell2 Location: Chr15:95117321-95426677 bp, - strand Genetic Position: Chr15, 49.39 cM, cytoband F1
• Alliance: Nell2^tm1Mho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89818
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons encoding the N-terminal region were replaced with a pMC1-neo cassette via homologous recombination. Northern blot and in situ analysis confirmed the absence of mRNA expression in homozygotes. (J:89818)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nell2 Mutation: 46 strains or lines available

References

• Original: J:89818 Matsuyama S, et al., Enhanced long-term potentiation in vivo in dentate gyrus of NELL2-deficient mice. Neuroreport. 2004 Mar 1;15(3):417-20
• All: 2 reference(s)