Tmod1^tm1Sung
Targeted Allele Detail

Summary

• Symbol: Tmod1^tm1Sung
• Name: tropomodulin 1; targeted mutation 1, Lanping Amy Sung
• MGI ID: MGI:3043840
• Synonyms: E-Tmod-
• Gene: Tmod1 Location: Chr4:46038940-46116032 bp, + strand Genetic Position: Chr4, 24.49 cM
• Alliance: Tmod1^tm1Sung page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89956
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette and LacZ gene via homologous recombination. LacZ expression under the control of the endogenous promoter was seen in the expected patterns. Western blot analysis confirmed the absence of protein in homozygous mice. (J:89956)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmod1 Mutation: 19 strains or lines available

References

• Original: J:89956 Chu X, et al., E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation. Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1827-38
• All: 2 reference(s)