Slc6a18^tm1Mca
Targeted Allele Detail

Summary

• Symbol: Slc6a18^tm1Mca
• Name: solute carrier family 6 (neurotransmitter transporter), member 18; targeted mutation 1, Marc G Caron
• MGI ID: MGI:3043846
• Synonyms: XT2^-/-
• Gene: Slc6a18 Location: Chr13:73809871-73826142 bp, - strand Genetic Position: Chr13, 40.13 cM
• Alliance: Slc6a18^tm1Mca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89891
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place of a genomic fragment encompassing exon 1 and a portion of intron 1 after a floxed neo cassette was excised via cre-mediated recombination. Absence of mRNA expression in homozygous mutant mice was verified by RT-PCR analysis. (J:89891)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a18 Mutation: 32 strains or lines available

References

• Original: J:89891 Quan H, et al., Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Mol Cell Biol. 2004 May;24(10):4166-73
• All: 2 reference(s)