Tg(Vav1-cre)1Awr
Transgene Detail

Summary

• Symbol: Tg(Vav1-cre)1Awr
• Name: transgene insertion 1, Andrew W Roberts
• MGI ID: MGI:3043860
• Synonyms: vavCre, VavCre^Croker
• Transgene: Tg(Vav1-cre)1Awr Location: unknown
• Alliance: Tg(Vav1-cre)1Awr page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Vav1-cre)1Awr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Vav1

• Mutation details: Sequence encoding nls-cre was adjoined to Vav1 promoter sequence. Cre activity was detected in hematopoietic cells including greater than 99% of neutrophils, macrophages, T cells and greater than 90% of B cells and nucleated erythroid cells. Activity was also detected in endothelial cells, and testes. (J:89785)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vav1 (species not specified) Summary of all recombinase alleles driven by Vav1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:89785 Croker BA, et al., SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity. 2004 Mar;20(2):153-65
• All: 17 reference(s)