Mutyh^tm1Jhmi
Targeted Allele Detail

Summary

• Symbol: Mutyh^tm1Jhmi
• Name: mutY DNA glycosylase; targeted mutation 1, Jeffrey H Miller
• MGI ID: MGI:3043929
• Synonyms: Myh^-
• Gene: Mutyh Location: Chr4:116664920-116676637 bp, + strand Genetic Position: Chr4, 53.34 cM, cytoband C7
• Alliance: Mutyh^tm1Jhmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89742
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 6, which encodes a conserved pseudo-helix-hairpin-helix motif, was disrupted by the insertion of a neo cassette. Transcript was undetected by RT-PCR analysis of RNA obtained from the livers of homozygous mutant mice. (J:89742)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mutyh Mutation: 36 strains or lines available

References

• Original: J:89742 Xie Y, et al., Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004 May 1;64(9):3096-102
• All: 22 reference(s)