Aldh1a3^tm1.1Pcn
Targeted Allele Detail

Summary

• Symbol: Aldh1a3^tm1.1Pcn
• Name: aldehyde dehydrogenase family 1, subfamily A3; targeted mutation 1.1, Pierre Chambon
• MGI ID: MGI:3043947
• Synonyms: Aldh1a3^KO, Aldh1a3^L-
• Gene: Aldh1a3 Location: Chr7:66040640-66077225 bp, - strand Genetic Position: Chr7, 35.73 cM, cytoband C
• Alliance: Aldh1a3^tm1.1Pcn page

Aldh1a3^tm1.1Pcn/Aldh1a3^tm1.1Pcn mice develop ocular and nasal defects

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was derived from Aldh1a3^tm1Pcn by crossing carriers of that allele with CMV-Cre expressing transgenics which results in the excision of exons 8 and 9 and thus the loss of the catalytic site in the protein product. (J:90261)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1a3 Mutation: 26 strains or lines available

References

• Original: J:90261 Dupe V, et al., A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14036-41
• All: 7 reference(s)