Sqstm1^tm1Jmos
Targeted Allele Detail

Summary

• Symbol: Sqstm1^tm1Jmos
• Name: sequestosome 1; targeted mutation 1, Jorge Moscat
• MGI ID: MGI:3043976
• Synonyms: p62^-
• Gene: Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
• Alliance: Sqstm1^tm1Jmos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90010
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of homozygous mutant embryonic fibroblasts. (J:90010)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqstm1 Mutation: 34 strains or lines available

References

• Original: J:90010 Duran A, et al., The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell. 2004 Feb;6(2):303-9
• All: 21 reference(s)