Nr4a2^tm1Omc
Targeted Allele Detail

Summary

• Symbol: Nr4a2^tm1Omc
• Name: nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Orla M Conneely
• MGI ID: MGI:3043985
• Synonyms: Nurr1^-
• Gene: Nr4a2 Location: Chr2:56996842-57014015 bp, - strand Genetic Position: Chr2, 31.66 cM
• Alliance: Nr4a2^tm1Omc page

Loss of Ptx3 expression and increased cell death in ventral midbrain region of newborn Nr4a2^tm1Omc/Nr4a2^tm1Omc mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46856
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette was inserted into exon 3, downstream of the start codon and upstream of the DNA-binding domain. (J:46856)

Disease models

Expression

In Mice Carrying this Mutation:	27 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr4a2 Mutation: 44 strains or lines available

References

• Original: J:46856 Saucedo-Cardenas O, et al., Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4013-8
• All: 15 reference(s)